A Novel Hybrid Model for Brain Tumor Analysis Using Dual Attention AtroDense U-Net and Auction Optimized LSTM Network

PDF (1891KB), PP.45-61

Views: 0 Downloads: 0

Author(s)

S. K. Rajeev 1,2,* M. Pallikonda Rajasekaran 3 R. Kottaimalai 3 T. Arunprasath 3 Nisha A.V. 2 Abdul Khader Jilani Saudagar 4

1. Department of Electronics & Communication Engineering, Kalasalingam Academy of Research and Education, TamilNadu, India

2. Department of Electronics and Communication Engineering, Younus College of Engineering and Technology, Kollam, Kerala, India

3. School of Electronics, Electrical and Biomedical Technology, Kalasalingam Academy of Research and Education, TamilNadu, India

4. Information Systems Department, College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University(IMSIU), Riyadh, Kingdom of Saudi Arabia

* Corresponding author.

DOI: https://doi.org/10.5815/ijisa.2026.01.04

Received: 7 Jul. 2025 / Revised: 24 Aug. 2025 / Accepted: 7 Oct. 2025 / Published: 8 Feb. 2026

Index Terms

Brain Tumor, Dual Attention U-Net Model, Gray Level Co-Occurrence Matrix (GLCM), Cat and Mouse Optimization, Long Short Term Memory

Abstract

Timely identification of brain tumors helps improve treatment outcomes and reduces mortality. Accurate and non-invasive diagnostic tools for segmenting and classifying tumor regions in brain MRI scans are crucial for minimizing the need for surgical biopsies. This study builds a deep learning model for tumor segmentation and classification, aiming high accuracy and efficiency. A gaussian bilateral filter is used for noise reduction and to improve MRI image quality. Tumor segmentation is performed using an advanced U-Net model, the Dual Attention AtroDense U-Net (DA-AtroDense U-Net), which integrates dense connections, atrous convolution and attention mechanisms to preserve spatial detail and improve boundary localization. Texture-based radiomic features are subsequently extracted from the segmented tumor  
region using Kirsch Edge Detector (KED) and Gray-Level Co-occurrence Matrix (GLCM) and refined through feature selection to reduce redundancy using the Cat-and-Mouse Optimization (CMO) algorithm. Tumor classification employs an Auction-Optimized hybrid LSTM Network (AOHLN). Evaluated on BraTS 2019 and 2020 datasets, the developed model achieved a Dice Similarity Coefficient of 0.9907 and a Jaccard Index of 0.9816 for segmentation accuracy and an overall accuracy of 98.99% for classification, highlighting its potential as a dependable and non-invasive diagnostic solution.

Cite This Paper

S. K. Rajeev, M. Pallikonda Rajasekaran, R. Kottaimalai, T. Arunprasath, Nisha A. V., Abdul Khader Jilani Saudagar, "A Novel Hybrid Model for Brain Tumor Analysis Using Dual Attention AtroDense U-Net and Auction Optimized LSTM Network", International Journal of Intelligent Systems and Applications(IJISA), Vol.18, No.1, pp.45-61, 2026. DOI:10.5815/ijisa.2026.01.04

Reference

[1]O. F. Sultana, M. Bandaru, M. A. Islam, and P. H. Reddy, “Unraveling the complexity of human brain: Structure, function in healthy and disease states,” Ageing Research Reviews, vol. 100, p. 102414, 2024.
[2]A. Di Ieva et al., “Application of deep learning for automatic segmentation of brain tumors on magnetic resonance imaging: A heuristic approach in the clinical scenario,” Neuroradiology, vol. 63, no. 8, pp. 1253–1262, 2021.
[3]Á. Győrfi, L. Szilágyi, and L. Kovács, “A fully automatic procedure for brain tumor segmentation from multi-spectral MRI records using ensemble learning and atlas-based data enhancement,” Applied Sciences, vol. 11, no. 2, p. 564, 2021.
[4]T. Zhou, S. Canu, P. Vera, and S. Ruan, “Latent correlation representation learning for brain tumor segmentation with missing MRI modalities,” IEEE Transactions on Image Processing, vol. 30, pp. 4263–4274, 2021.
[5]W. You et al., “The combination of radiomics features and VASARI standard to predict glioma grade,” Frontiers in Oncology, vol. 13, p. 1083216, 2023.
[6]V. A. Mulimani, S. S. Sannakki, and V. S. Rajpurohit, “A systematic review of clustering and classifier techniques for brain tumor segmentation in MRI images,” International Journal of Computer Vision and Image Processing, vol. 11, no. 2, pp. 46–57, 2021.
[7]K. Hao, S. Lin, J. Qiao, and Y. Tu, “A generalized pooling for brain tumor segmentation,” IEEE Access, vol. 9, pp. 159283–159290, 2021.
[8]N. A. V., M. P. Rajasekaran, R. K. Priya, and A. Al Bimani, “Artificial intelligence-based neurodegenerative disease diagnosis and research analysis using functional MRI (fMRI): A review,” in Proc. 3rd Int. Conf. Advances in Computing, Communication Control and Networking (ICAC3N), Greater Noida, India, 2021, pp. 446–450, doi: 10.1109/ICAC3N53548.2021.9725691.
[9]Nisha. A. V.et al,, “Metaheuristic-enhanced deep learning model for accurate Alzheimer’s disease diagnosis from MRI imaging,” International Journal of Intelligent Systems and Applications (IJISA), vol. 17, no. 1, pp. 70–87, 2025, doi: 10.5815/ijisa.2025.01.05
[10]J. Kang, Z. Ullah, and J. Gwak, “MRI-based brain tumor classification using ensemble of deep features and machine learning classifiers,” Sensors, vol. 21, no. 6, p. 2222, 2021.
[11]A. K. Anaraki, M. Ayati, and F. Kazemi, “Magnetic resonance imaging-based brain tumor grades classification and grading via convolutional neural networks and genetic algorithms,” Biocybernetics and Biomedical Engineering, vol. 39, no. 1, pp. 63–74, 2019.
[12]W. Zhang et al., “ME-Net: Multi-encoder net framework for brain tumor segmentation,” International Journal of Imaging Systems and Technology, vol. 31, no. 4, pp. 1834–1848, 2021.
[13]S. K. Rajeev, M. P. Rajasekaran, R. K. Priya, and A. Al Bimani, “A review on magnetic resonance spectroscopy for clinical diagnosis of brain tumour using deep learning,” in Proc. 3rd Int. Conf. Advances in Computing, Communication Control and Networking (ICAC3N), Greater Noida, India, 2021, pp. 461–465, doi: 10.1109/ICAC3N53548.2021.9725561.
[14]S. Iqbal, A. N. Qureshi, M. Alhussein, K. Aurangzeb, I. A. Choudhry, and M. S. Anwar, “Hybrid deep spatial and statistical feature fusion for accurate MRI brain tumor classification,” Front. Comput. Neurosci., vol. 18, p. 1423051, 2024, doi: 10.3389/fncom.2024.1423051.
[15]A. Akter et al., “Robust clinical applicable CNN and U-Net based algorithm for MRI classification and segmentation for brain tumor,” Expert Systems with Applications, vol. 238, p. 122347, 2024.
[16]A. A. Asiri, T. A. Soomro, A. A. Shah, G. Pogrebna, M. Irfan, and S. Alqahtani, “Optimized Brain Tumor Detection: A Dual-Module Approach for MRI Image Enhancement and Tumor Classification,” IEEE Access, vol. 12, pp. 42868–42887, 2024, doi: 10.1109/ACCESS.2024.3379136.
[17]N. A. Zebari et al., “A deep learning fusion model for accurate classification of brain tumours in magnetic resonance images,” CAAI Transactions on Intelligence Technology, vol. 9, no. 4, pp. 790–804, 2024.
[18]A. Alshuhail et al., “Refining neural network algorithms for accurate brain tumor classification in MRI imagery,” BMC Medical Imaging, vol. 24, no. 1, p. 118, 2024.
[19]S. Natha, U. Laila, I. A. Gashim, K. Mahboob, M. N. Saeed, and K. M. Noaman, “Automated Brain Tumor Identification in Biomedical Radiology Images: A Multi-Model Ensemble Deep Learning Approach,” Applied Sciences, vol. 14, no. 5, p. 2210, Mar. 2024, doi: 10.3390/app14052210.
[20]S. M. Alqhtani et al., “Improved brain tumor segmentation and classification in brain MRI with FCM-SVM: A diagnostic approach,” IEEE Access, vol. 12, pp. 61312–61335, 2024.
[21]A. R. Khan et al., “Brain tumor segmentation using K-means clustering and deep learning with synthetic data augmentation for classification,” Microscopy Research and Technique, vol. 84, no. 7, pp. 1389–1399, 2021.
[22]N. M. Aboelenein, P. Songhao, A. Koubaa, A. Noor, and A. Afifi, “HTTU-Net: Hybrid two track U-Net for automatic brain tumor segmentation,” IEEE Access, vol. 8, pp. 101406–101415, 2020.
[23]F. J. Díaz-Pernas, M. Martínez-Zarzuela, M. Antón-Rodríguez, and D. González-Ortega, “A deep learning approach for brain tumor classification and segmentation using a multiscale convolutional neural network,” Healthcare, vol. 9, no. 2, p. 153, 2021.
[24]D. R. Nayak, N. Padhy, P. K. Mallick, M. Zymbler, and S. Kumar, “Brain tumor classification using dense Efficient-Net,” Axioms, vol. 11, no. 1, p. 34, 2022.
[25]S. K. Rajeev, M. P. Rajasekaran, G. Vishnuvarthanan, and T. Arunprasath, “A biologically-inspired hybrid deep learning approach for brain tumor classification from magnetic resonance imaging using improved Gabor wavelet transform and Elmann-BiLSTM network,” Biomedical Signal Processing and Control, vol. 78, p. 103949, 2022.
[26]W. R. Khan et al., “A Hybrid Attention-Based Residual Unet for Semantic Segmentation of Brain Tumor,” Comput. Mater. Contin., vol. 76, no. 1, pp. 647–664, 2023. https://doi.org/10.32604/cmc.2023.039188
[27]S.-Y. Lin and C.-L. Lin, “Brain tumor segmentation using U-Net in conjunction with EfficientNet,” PeerJ Computer Science, vol. 10, p. e1754, 2024, doi: 10.7717/peerj-cs.1754
[28]P. Li, Z. Li, Z. Wang, et al., “mResU-Net: multi-scale residual U-Net-based brain tumor segmentation from multimodal MRI,” Medical & Biological Engineering & Computing, vol. 62, pp. 641–651, 2024, doi: 10.1007/s11517-023-02965-1.
[29]B. H. Menze, A. Jakab, S. Bauer, J. Kalpathy-Cramer, K. Farahani, J. Kirby, et al. "The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS)", IEEE Transactions on Medical Imaging 34(10), 1993-2024 (2015) DOI: 10.1109/TMI.2014.2377694 
[30]S. Bakas, H. Akbari, A. Sotiras, M. Bilello, M. Rozycki, J.S. Kirby, et al., "Advancing The Cancer Genome Atlas glioma MRI collections with expert segmentation labels and radiomic features", Nature Scientific Data, 4:170117 (2017) DOI: 10.1038/sdata.2017.117
[31]S. Bakas, M. Reyes, A. Jakab, S. Bauer, M. Rempfler, A. Crimi, et al., "Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge", arXiv preprint arXiv:1811.02629 (2018)
[32]F. Isensee, P. F. Jaeger, S. A. A. Kohl, et al., “nnU-Net: A self-configuring method for deep learning-based biomedical image segmentation,” Nature Methods, vol. 18, pp. 203–211, 2021, doi: 10.1038/s41592-020-01008-z.