IJEM Vol. 16, No. 2, 8 Apr. 2026
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Lung Cancer Detection, Computed Tomography, Deep Learning, Convolutional Neural Networks, Hybrid Model, Medical Imaging
Lung cancer is responsible for many deaths from cancer around the globe, primarily because it is difficult to find malignant lung nodules early enough to be treatable. We developed a hybrid deep learning approach to the automated classification of lung nodules from chest computed tomography (CT) images. Our model uses convolutional neural networks (CNNs) for hierarchical feature extraction, an attention mechanism for feature refinement in targeted regions of interest, and a support vector machine (SVM) classifier for robust margin-based decision making. Furthermore, we use a patch-based learning strategy within the model to improve sensitivity to small and ambiguous lung nodules. The model is tested on the publicly available LIDC-IDRI dataset and achieves 94.2% accuracy, 95.1% recall, and an area under the receiver operating characteristic curve (AUC-ROC) score of 0.971, which outperforms multiple baseline deep learning methods. The proposed method provides a synergistic integration of attention-weighted feature enhancements and traditional machine learning classifications as compared to traditional end-to-end architectures, resulting in improved model generalization and interpretability. Grad-CAM visualizations are also used to provide qualitative insights into the model decision-making process. The proposed hybrid approach provides a novel and interpretable solution for the classification of lung nodules from CT images that may assist in the development of computerized systems to assist physicians in making diagnoses using medical images.
Mukesh Kumar, Vivek Bhardwaj, Kavita Dhiman, Ahmed Qtaishata, "Deep Learning Method for Early Detection of Lung Cancer using Deep Learning Algorithms", International Journal of Engineering and Manufacturing (IJEM), Vol.16, No.2, pp.171-184, 2026. DOI:10.5815/ijem.2026.02.11
[1]Sharma, R., Sharma, I., Jain, N., & Bansal, M. (2026). Early Detection of Lung Cancer Using Swarm Intelligence and Deep Learning: A Synergistic Approach. In Innovative Computing and Communications: Proceedings of ICICC 2025, Volume 8 (pp. 147-152). Singapore: Springer Nature Singapore.
[2]Radhika, P. R., Nair, R. A., & Veena, G. (2019, February). A comparative study of lung cancer detection using machine learning algorithms. In 2019 IEEE international conference on electrical, computer and communication technologies (ICECCT) (pp. 1-4). IEEE.
[3]Sun, W., Zheng, B., & Qian, W. (2016, March). Computer aided lung cancer diagnosis with deep learning algorithms. In Medical imaging 2016: computer-aided diagnosis (Vol. 9785, pp. 241-248). SPIE.
[4]Meeradevi, T., Sasikala, S., Murali, L., Manikandan, N., & Ramaswamy, K. (2025). Lung cancer detection with machine learning classifiers with multi-attribute decision-making system and deep learning model. Scientific Reports, 15(1), 8565.
[5]Wankhade, S., & Vigneshwari, S. (2023). A novel hybrid deep learning method for early detection of lung cancer using neural networks. Healthcare Analytics, 3, 100195.
[6]Gote, P. M., Kumar, P., Kumar, H., Verma, P., &Jiet, M. M. (2025). Integrating Machine Learning Algorithms: A Hybrid Model for Lung Cancer Outcome Improvement. Applied Sciences, 15(9), 4637.
[7]Ozdemir, B., Aslan, E., & Pacal, I. (2025). Attention Enhanced InceptionNeXt Based Hybrid Deep Learning Model for Lung Cancer Detection. IEEE Access.
[8]Ansari, M. M., Kumar, S., Heyat, M. B. B., Ullah, H., Hayat, M. A. B., Sumbul, ... & Zhang, T. (2025). SVMVGGNet-16: A Novel Machine and Deep Learning Based Approaches for Lung Cancer Detection using Combined SVM and VGGNet-16. Current Medical Imaging, 21(1), e15734056348824.
[9]Aggrey, E. S. E., Zhen, Q., Kodjiku, S. L., Fiasam, L. D., Sey, C., Ukwuoma, C. C., ... & Osei-Mensah, E. (2025). Towards precision diagnosis: a novel hybrid DC-CAD model for lung disease detection leveraging multi-scale capsule networks and temporal dynamics. Complex & Intelligent Systems, 11(6), 1-24.
[10]Bharathi, P. S., & Shalini, C. (2024). Advanced hybrid attention-based deep learning network with heuristic algorithm for adaptive CT and PET image fusion in lung cancer detection. Medical Engineering & Physics, 126, 104138.
[11]Hossain, M. S., Basak, N., Mollah, M. A., Nahiduzzaman, M., Ahsan, M., & Haider, J. (2025). Ensemble-based multiclass lung cancer classification using hybrid CNN-SVD feature extraction and selection method. PLoS One, 20(3), e0318219.
[12]Kusuma, S., Krishnan, S. G., Samreen, K., Ramana, M. V., & Prasad, G. S. (2024, March). A Hybrid Deep Learning Approach for Early Detection and Classification of Lung Cancer Using the Pelican Optimization Algorithm. In 2024 International Conference on Distributed Computing and Optimization Techniques (ICDCOT) (pp. 1-6). IEEE.
[13]Vijh, S., Gaurav, P., & Pandey, H. M. (2023). Hybrid bio-inspired algorithm and convolutional neural network for automatic lung tumor detection. Neural Computing and Applications, 35(33), 23711-23724.
[14]Salam, M. A., Abdellatif, A., Abdallah, M., & Salam, N. A. (2025). A Hybrid Deep Learning and Machine Learning Model for Multi-Class Lung Disease Detection in Medical Imaging. International Journal of Intelligent Engineering & Systems, 18(1).
[15]Venkatesh, C., Chinna Babu, J., Kiran, A., Nagaraju, C. H., & Kumar, M. (2024). A hybrid model for lung cancer prediction using patch processing and deep learning on CT images. Multimedia Tools and Applications, 83(15), 43931-43952.
[16]El Guabassi, I., Bousalem, Z., Marah, R., & Haj, A. (2025). A Hybrid Data Mining Model for Early Detection of Lung Cancer Utilizing Supervised Feature Extraction. In The Proceedings of the International Conference on Smart City Applications (pp. 42-52). Springer, Cham.
[17]Lisha, R., Agees Kumar, C., & Ajith Bosco Raj, T. (2025). Deep Learning‐Assisted Computer‐Aided Diagnosis System for Early Detection of Lung Cancer. Journal of Clinical Ultrasound.
[18]Nusantoro, J., Soesanti, I., & Ardiyanto, I. (2024, August). Lung Cancer Detection Algorithm and Method Using Deep Learning Techniques: A Systematic Literature Review. In 2024 4th International Conference on Electronic and Electrical Engineering and Intelligent System (ICE3IS) (pp. 75-80). IEEE.
[19] Güraksın, G. E., & Kayadibi, I. (2025). A Hybrid LECNN Architecture: A Computer-Assisted Early Diagnosis System for Lung Cancer Using CT Images. International Journal of Computational Intelligence Systems, 18(1), 35.
[20]Al-Shabi, M., Shak, K., & Tan, M. (2022). ProCAN: Progressive growing channel attentive non-local network for lung nodule classification. Pattern Recognition, 122, 108309.
[21]Keel, B., Quyn, A., Jayne, D., & Relton, S. D. (2023). Variational Autoencoders for Feature Exploration and Malignancy Prediction of Lung Lesions. arXiv preprint arXiv:2311.15719.
[22]Zhu, W., Liu, C., Fan, W., & Xie, X. (2018, March). Deep lung: Deep 3d dual path nets for automated pulmonary nodule detection and classification. In 2018 IEEE winter conference on applications of computer vision (WACV) (pp. 673-681). IEEE.
[23]Al-Shabi, M., Lee, H. K., & Tan, M. (2019). Gated-dilated networks for lung nodule classification in CT scans. IEEE Access, 7, 178827-178838.
[24]Müller-Franzes, G., Khader, F., Siepmann, R., Han, T., Kather, J. N., Nebelung, S., & Truhn, D. (2024). Medical Slice Transformer: Improved Diagnosis and Explainability on 3D Medical Images with DINOv2. arXiv preprint arXiv:2411.15802.
[25]Harsono, I. W., Liawatimena, S., & Cenggoro, T. W. (2022). Lung nodule detection and classification from Thorax CT-scan using RetinaNet with transfer learning. Journal of King Saud University-Computer and Information Sciences, 34(3), 567-577.
[26]Jiang, H., Shen, F., Gao, F., & Han, W. (2021). Learning efficient, explainable, and discriminative representations for pulmonary nodules classification. Pattern Recognition, 113, 107825.
[27]Al-Shabi, M., Lan, B. L., Chan, W. Y., Ng, K. H., & Tan, M. (2019). Lung nodule classification using deep local–global networks. International journal of computer assisted radiology and surgery, 14, 1815-1819.