IJEME Vol. 15, No. 3, 8 Jun. 2025
Cover page and Table of Contents: PDF (size: 936KB)
PDF (936KB), PP.24-39
Views: 0 Downloads: 0
Chronic Kidney Disease, Machine Learning, Explainable AI, SHAP, Early Detection
Chronic Kidney Disease (CKD) is considered a leading cause of high morbidity and mortality. Therefore, it needs early detection to allow timely intervention aimed at the enhancement of the patient outcome. The current study presents a Transparent CKD ML which combines the predictive power of efficient ML methods with the eXplainable AI techniques for transparent interpretibility of the prediction. This study has conducted an in-depth performance evaluation of the predictive power of the following eight machine learning algorithms: Logistic Regression, K-Nearest Neighbours (KNN), Support Vector Machine (SVM), Decision Tree, Random Forest, CatBoost, XGBoost, and AdaBoost on the 'Chronic Kidney Disease' dataset provided by UCI Machine Learning Repository. As a further study on algorithm performance, performance measures of accuracy, precision, recall, and F1 score were calculated; it was determined that Logistic Regression, Random Forest, and AdaBoost were performing very well and achieved 100% score in all metrics. This study further combined the ML models with eXplainable AI ( XAI) techniques to increase the transparency of the models. SHapley Additive exPlanations (SHAP) an XAI technique was used to provide critical insights into the causality that dictates the predictions of CKD. Thus, this combination ensures the best performance of the model, increasing the trust in AI within clinical practice. The present study, therefore, unleashes the transformational potential of AI technologies in radically renovating the management of CKD and improving patient outcomes across the world.
Abhinav Shivhare, A. Charan Kumari, K. Srinivas, "Predictive Modeling for Chronic Kidney Disease: A Comparative Analysis of Machine Learning Techniques with Explainable AI for Clinical Transparency", International Journal of Education and Management Engineering (IJEME), Vol.15, No.3, pp. 24-39, 2025. DOI:10.5815/ijeme.2025.03.03
[1]Global Facts: About Kidney Disease. Available at https://www.kidney.org/kidneydisease/global-facts-about-kidney-disease/. Accessed 9 May 2024
[2]Ma F, Sun T, Liu L, Jing H (2020) Detection and diagnosis of chronic kidney disease using deep learning-based heterogeneous modified artificial neural network. Future Generation Computer Systems, 111:17–26. 10.1016/j.future.2020.04.036
[3]National Kidney Foundation. Chronic Kidney Disease (CKD). Available at https://www.kidney.org/atoz/content/about-chronic-kidney-disease. Accessed 9 May 2024.
[4]Kalaiselvi, K., V. J. Sara, S.B. (2022). A Hybrid Filter Wrapper Embedded-Based Feature Selection for Selecting Important Attributes and Prediction of Chronic Kidney Disease. In: Ramu, A., Chee Onn, C., Sumithra, M. (eds) International Conference on Computing, Communication, Electrical and Biomedical Systems. EAI/Springer Innovations in Communication and Computing. Springer, Cham. https://doi.org/10.1007/978-3-030-86165-0_14
[5]Henry, B.M., Lippi, G. (2020) Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection. Int Urol Nephrol 52, 1193–1194. https://doi.org/10.1007/s11255-020-02451-9
[6]Estimated Glomerular Filtration Rate (eGFR) Available at https://www.kidney.org/atoz/content/gfr. Accessed 9 May 2024.
[7]Shehab M, Abualigah L, Shambour Q, Abu-Hashem MA, Shambour MKY, Alsalibi AI, Gandomi AH (2022). Machine learning in medical applications: A review of state-of-the-art methods. Computers in Biology and Medicine 145:105458. https://doi.org/10.1016/j.compbiomed.2022.105458.
[8]Charleonnan A, Fufaung T, Niyomwong T, Chokchueypattanakit W, Suwannawach S, Ninchawee N (2017) Predictive analytics for chronic kidney disease using machine learning techniques. Management and Innovation Technology International Conference (MITicon), DOI: 10.1109/MITICON.2016.8025242.
[9]Bhaskar N, Suchetha M: An Approach for Analysis and Prediction of CKD using Deep Learning Architecture (2020). International Conference on Communication and Electronics Systems (ICCES), DOI: 10.1109/ICCES45898.2019.9002214.
[10]Senan EM, Al-Adhaileh MH, Alsaade FW, Aldhyani THH, Alqarni AA, Alsharif N, Uddin MI, Alahmadi AH, Jadhav ME, Alzahrani MY(2021). Diagnosis of chronic kidney disease using effective classification algorithms and recursive feature elimination techniques. Journal of Healthcare Engineering: 1–10. https://doi.org/10.1155/2021/1004767
[11]Janani J, Sathyaraj R (2021) Diagnosing Chronic Kidney Disease Using Hybrid Machine Learning Techniques. Turkish Journal of Computer and Mathematics Education, 12: 6383–6390.
[12]Chittora P, Chaurasia S, Chakrabarti P, Kumawat G, Chakrabarti T, Leonowicz Z, Jasinski M, Jasinski L, Gono R, Jasinska E, Bolshev V (2021) Prediction of Chronic Kidney Disease - A Machine Learning Perspective. IEEE Access, DOI: 10.1109/ACCESS.2021.3053763.
[13]Nikhila: Chronic Kidney Disease Prediction using Machine Learning Ensemble Algorithm (2021) International Conference on Computing, Communication, and Intelligent Systems (ICCCIS), DOI: 10.1109/ICCCIS51004.2021.
[14]Singh V, Asari VK, Rajasekaran R (2022) A Deep Neural Network for Early Detection and Prediction of Chronic Kidney Disease. Diagnostics, 12: 116. 10.3390/diagnostics12010116
[15]Abdel-Fattah MA, Othman NA, Goher N (2022) Predicting Chronic Kidney Disease Using Hybrid Machine Learning Based on Apache Spark. Computational Intelligence and Neuroscience: 1–12. https://doi.org/10.1155/2022/9898831
[16]Latha Busi RA, Meka JS, Reddy PVGDP (2023) A Hybrid Deep Learning Technique for Feature Selection and Classification of Chronic Kidney Disease. International Journal of Intelligent Engineering and Systems,16: 638–649.
[17]Ghosh, S.K., Khandoker, A.H (2014) Investigation on explainable machine learning models to predict chronic kidney diseases. Sci Rep 14, 3687. https://doi.org/10.1038/s41598-024-54375-4
[18]Rubini, L., Soundarapandian,P., and Eswaran,P. (2015). Chronic Kidney Disease. UCI Machine Learning Repository. https://doi.org/10.24432/C5G020.